EPIRUBICIN IN PATIENTS WITH ADVANCED OR RECURRENT ADENOID CYSTIC CARCINOMA OF THE HEAD AND NECK - A PHASE-II STUDY OF THE EORTC HEAD AND NECK-CANCER COOPERATIVE GROUP

Background: Because of the rarity of salivary gland cancer, little is known about the single-agent activity of most anticancer agents in the different histologic types of these cancers. Patients and methods: Tw enty patients with advanced or recurrent adenoid cystic carcinoma of t he head and neck were treated with epirubicin on a low-dose weekly sch edule (30 mg/ml/week) for eight weeks and, in instances of no response , a high-dose three-weekly schedule (greater-than-or-equal-to 90 mg/m2 ). Thirteen patients had locoregional disease (12 recurrences), seven of them also had distant metastases and seven had distant metastases o nly. All had documented progressive disease, and 17 were symptomatic. Results: Two objective responses of 7.5 and 20 months were observed in patients with locally recurrent disease, and ten patients showed dise ase stabilization. The median time to progression was 16 weeks (range 2-250 weeks) and the median survival 67 weeks (range 13-272+ weeks), w ith three patients still alive more than five years after the initiati on of chemotherapy. Contrary to the rather modest objective response r ate, symptomatic improvement occurred more frequently (29.4%) and was evident within 8 weeks of treatment. Conclusions: This type of chemoth erapy should be reserved for patients with rapidly progressive disease or those with symptomatic disease.