H. Ogawa et al., DIFFERENCE IN PLASMINOGEN-ACTIVATOR INHIBITOR ACTIVITY BETWEEN NON-Q-WAVE INFARCTION AND Q-WAVE INFARCTION, International journal of cardiology, 41(3), 1993, pp. 201-208
We examined the plasma levels of tissue plasminogen activator antigen
and plasminogen activator inhibitor activity in 14 patients with non-Q
-wave infarction and in 27 patients with Q-wave infarction before the
start of thrombolytic therapy and in 34 control subjects. The mean lev
el of plasma tissue plasminogen activator antigen (ng/ml) was higher (
P < 0.01) both in the patients with non-Q-wave infarction and in those
with Q-wave infarction than in the control subjects (10.3 +/- 1.9, 9.
5 +/- 0.8 vs. 5.8 +/- 0.3), and there was no difference in the level b
etween the patients with non-Q-wave infarction and those with Q-wave i
nfarction. The mean level of plasma plasminogen activator inhibitor ac
tivity (IU/ml) was lower (P < 0.01) in the patients with non-Q-wave in
farction than in those with Q-wave infarction (7.3 +/- 2.0 vs. 17.1 +/
- 2.2), and there was no difference in the level between the patients
with non-Q-wave infarction and the control subjects (7.3 +/- 2.0 vs. 4
.1 +/- 2.6). The patency rate of infarct-related coronary artery befor
e thrombolytic therapy was higher (P < 0.01) in the patients with non-
Q-wave infarction than in those with Q-wave infarction (54% vs. 15%).
We conclude that plasminogen activator inhibitor activity was lower in
non-Q-wave infarction than in Q-wave infarction and this may be relat
ed to the higher patency rate of infarct-related coronary artery in no
n-Q-wave infarction.