THE PROPHYLACTIC EFFECTS OF SUPEROXIDE-DISMUTASE, CATALASE, DESFERRIOXAMINE, VERAPAMIL AND DISULFIRAM IN EXPERIMENTAL COLITIS

In our study we have tried to compare the prophylactic effects of supe roxide dismutase (SOD), SOD+catalase (CAT), desferrioxamine, verapamil and disulfiram, which are all free oxygen radical (FOR) scavengers, i n an animal model of experimental acetic acid colitis. The control gro up had 58.3% colonic ulcers. The SOD group (48.6% ulcerated area) and the SOD+CAT group (47.2% ulcerated area) did not show a significant di fference when compared with the control group. The values were signifi cantly different in all other groups when compared with the control gr oup (desferrioxamine (29.2% ulcerated area): P < 0.01;verapamil (10.4% ulcerated area) and disulfiram (7.6% ulcerated area): P < 0.001. In c onclusion, desferrioxamine, verapamil and disulfiram have been found t o be effective as prophylactics in experimental acetic acid colitis.