ANTIEMETIC PROFILE OF A NONPEPTIDE NEUROKININ-NK(1) RECEPTOR ANTAGONIST, CP-99,994, IN FERRETS

Authors
BOUNTRA C BUNCE K DALE T GARDNER C JORDAN C TWISSELL D WARD P
Citation
C. Bountra et al., ANTIEMETIC PROFILE OF A NONPEPTIDE NEUROKININ-NK(1) RECEPTOR ANTAGONIST, CP-99,994, IN FERRETS, European journal of pharmacology, 249(1), 1993, pp. 180000003-180000004
Citations number
2
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
European journal of pharmacology → ACNP
ISSN journal
00142999
Volume
249
Issue
1
Year of publication
1993
Pages
180000003 - 180000004
Database
ISI
SICI code
0014-2999(1993)249:1<180000003:APOANN>2.0.ZU;2-3
Abstract
In the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emeti c reflex pathway, we have examined the anti-emetic effects of a NK1 re ceptor antagonist (racemic CP-99,994) in the ferret. Racemic CP-99,994 was effective against a range of emetogens, comprising cytotoxic drug s, radiation, morphine, ipecacuanha and copper sulphate.