EXPRESSION OF PLASMINOGEN ACTIVATORS AND THEIR INHIBITORS IN HUMAN PANCREATIC-CARCINOMA - IMMUNOHISTOCHEMICAL STUDY

Citation
Y. Takeuchi et al., EXPRESSION OF PLASMINOGEN ACTIVATORS AND THEIR INHIBITORS IN HUMAN PANCREATIC-CARCINOMA - IMMUNOHISTOCHEMICAL STUDY, The American journal of gastroenterology, 88(11), 1993, pp. 1928-1933
Citations number
29
Categorie Soggetti
Gastroenterology & Hepatology
ISSN journal
00029270
Volume
88
Issue
11
Year of publication
1993
Pages
1928 - 1933
Database
ISI
SICI code
0002-9270(1993)88:11<1928:EOPAAT>2.0.ZU;2-V
Abstract
Expression of plasminogen activators (PA), tissue type (t-PA) and urok inase type (u-PA), as well as PA inhibitors (PAI), type-1 (PAI-1) and type 2 (PAI-2), were investigated immunohistochemically in 97 human pa ncreatic carcinomas. u-PA expression predominated in pancreatic carcin omas, compared with t-PA [u-PA expression in 76 specimens (78.4%) and t-PA in eight specimens (8.2%)]. PAI-1 expression was detected in 80 c arcinoma specimens (82.5%) and PAI-2 in 79 carcinoma specimens (81.4%) . PAI-2 expression was significantly lower in carcinomas with peritone al metastasis (p < 0.02). Strong PAI-2 expression was associated with significantly higher survival than negative or weak PAI-2 expression ( p < 0.05). We conclude that immunohistochemical analysis of PAI-2 expr ession in pancreatic carcinomas may yield important prognostic in form ation.