To date 25 controlled therapy studies have investigated the antidepres
sive effectiveness of hypericum extracts. A total of 1592 treatment ca
ses have been included. The dosage was typically 300 - 900 mg total ex
tract daily; the therapy durations 2-6 weeks. 15 studies were performe
d comparing hypericum extracts with placebo, 10 studies as comparative
studies. Eleven of those studies are subsequently published in this i
ssue of the journal >>Nervenheilkunde<<.