Currently somatotropin in being developed for use in several animal sp
ecies, primarily as a productivity enhancer. The objective of this pap
er was fo review direct and indirect effects of somatotropin supplemen
tation on reproduction particularly in the dairy cow. There is substan
tial evidence that somatotropin plays an important role in the normal
ovarian function. This effect is probably mediated via IGF-1. Existing
literature indicates that higher milk yields are antagonistic to repr
oductive performance and require enhanced nutrition and reproductive m
anagement. Similarly, studies indicate that reproductive performance m
ay be impaired in dairy cattle supplemented with somatropin. Effects o
f somatotropin treatment on reproductive performance may depend on me
dose and the stage of lactation. Low doses of somatotropin in early la
ctation may improve reproductive function.