ISOLATION AND GENOMIC ANALYSIS OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-II FROM GHANA

Authors
IGARASHI T YAMASHITA M MIURA T OSEIKWASI M AYSI NK SHIRAKI H KURIMURA T HAYAMI M
Citation
T. Igarashi et al., ISOLATION AND GENOMIC ANALYSIS OF HUMAN T-LYMPHOTROPIC VIRUS TYPE-II FROM GHANA, AIDS research and human retroviruses, 9(10), 1993, pp. 1039-1042
Citations number
12
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
AIDS research and human retroviruses → ACNP
ISSN journal
08892229
Volume
9
Issue
10
Year of publication
1993
Pages
1039 - 1042
Database
ISI
SICI code
0889-2229(1993)9:10<1039:IAGAOH>2.0.ZU;2-4
Abstract
An HTLV-II was isolated from a Ghanaian female patient with ARC and an ti-HTLV-II antibody by cocultivation of PBMC with Molt-4 cells. A part of the 5' LTR of this virus was sequenced. Sequence homology between this virus and the corresponding sequence of Mo, the prototype of HTLV -II, is 97.4%. Furthermore, this virus is a member of the HTLV-IIa gro up, which was proposed by Hall et al.11 This is the first report of an HTLV-II sequence from Africa confirmed not only by serological eviden ce, but also by genomic analysis. This finding will provide useful inf ormation for considering the spread of HTLV-II in the world and the ev olution of the HTLV group.