The main aim of percutaneous nucleotomy techniques is to reduce the vo
lume and pressure of the affected disc while leaving all other structu
res unaffected. Previously percutaneous discectomies were performed un
der fluoroscopic guidance with or without endoscopy. In this paper we
describe the combination of CT-scanning and fluoroscopy for guidance o
f nucleotomes, lasers, microendoscopes and other microinstruments. The
results of percutaneous laser nucleotomy performed on 116 out-patient
s with chronic back pain are reported. Immediate pain relief was obtai
ned in 92% of the patients, and improvement of neurological deficits i
n 59%. After 6 weeks, 87% of patients were back at work. At follow-up,
1-17 months later, overall improvement of pain symptoms of 50-100% wa
s present in 81% of the patients; the results were better in patients
with longer follow-up times. Spondylodiscitis occurred in one patient
and a second herniation with re-operation in five patients. These resu
lts show that effective treatment of disc herniation is possible on an
out-patient basis. The integration of knowledge from the fields of in
terventional radiology and minimally invasive surgery will lead to inc
reased use of microtherapy. This kind of therapy can become an importa
nt factor in cost reduction in health care systems worldwide.