TRANSMISSION CHARACTERISTICS OF A RADIOFREQUENCY QUADRUPOLE FOR MS MS/

Citation
Mg. Bartlett et Kl. Busch, TRANSMISSION CHARACTERISTICS OF A RADIOFREQUENCY QUADRUPOLE FOR MS MS/, Analytical instrumentation, 21(3-4), 1993, pp. 123-140
Citations number
21
Categorie Soggetti
Instument & Instrumentation","Chemistry Analytical
Journal title
ISSN journal
07435797
Volume
21
Issue
3-4
Year of publication
1993
Pages
123 - 140
Database
ISI
SICI code
0743-5797(1993)21:3-4<123:TCOARQ>2.0.ZU;2-H
Abstract
Ion transmission through an RF-only quadrupole is affected by both the frequency and voltage applied to the quadrupole. With a change in the collision cell voltage, ion abundances for both precursor and product ions are seen to vary in a modulated fashion. This pattern of ion abu ndances has been described as quadrupole ''nodes'', with changes in io n abundances within a factor of 2-4 from maximum to minimum abundance. These nodes hamper MS/MS spectral reproducibility from instrument to instrument and can camouflage trends observed in energy-resolved MS/MS (ERMS/MS). We find ion abundance nodes to be present for both product and precursor ions, and the collision energies at which the nodes max imize appear to be unique to each mass.