THE EFFECT OF INDOMETHACIN UPON CEREBRAL BLOOD-FLOW IN HEALTHY-VOLUNTEERS - THE INFLUENCE OF MODERATE HYPOXIA AND HYPERCAPNIA

Authors
JENSEN K FREUNDLICH M BUNEMANN L THERKELSEN K HANSEN H COLD GE
Citation
K. Jensen et al., THE EFFECT OF INDOMETHACIN UPON CEREBRAL BLOOD-FLOW IN HEALTHY-VOLUNTEERS - THE INFLUENCE OF MODERATE HYPOXIA AND HYPERCAPNIA, Acta neurochirurgica, 124(2-4), 1993, pp. 114-119
Citations number
26
Categorie Soggetti
Surgery,Neurosciences
Journal title
Acta neurochirurgica → ACNP
ISSN journal
00016268
Volume
124
Issue
2-4
Year of publication
1993
Pages
114 - 119
Database
ISI
SICI code
0001-6268(1993)124:2-4<114:TEOIUC>2.0.ZU;2-4
Abstract
In a randomized study of healthy volunteers indomethacin bolus injecti on followed by continuous infusion decreased CBF from normal levels ra nging from 45 to 80 ml/100 g/min to levels ranging from 24 to 57 ml/10 0 g/min. These low levels were sustained during a six hour infusion pe riod. Periods of hypoxia during inhalation of 17% oxygen and hypercapn ia during inhalation of 2-4% CO2 normalized CBF.