HUMAN MONOCLONAL-ANTIBODY FAB FRAGMENTS CLONED FROM COMBINATORIAL LIBRARIES - POTENTIAL USEFULNESS IN PREVENTION AND OR TREATMENT OF MAJOR HUMAN VIRAL DISEASES/

Currently, there is increased interest in the use of human viral antib odies for prophylaxis and therapy because recent advances in molecular immunology have made it possible to generate large numbers of human m onoclonal antibodies of desired specificity and functional activity in short order. The strategy, developed particularly at The Scripps Rese arch Institute and at Cambridge University is based on antigen selecti on of such antibodies from combinatorial libraries that express Fabs o n the surface of filamentous DNA bacteriophage. Fabs or their whole im munoglobulin derivatives that exhibit high avidity for the selecting a ntigen and high neutralizing activity for the corresponding virus have been identified, and many of these human monoclonal antibodies should prove to be useful in prophylaxis or therapy of presently uncontrolle d, medically important human viral diseases.