CONCENTRATIONS OF VASOACTIVE INTESTINAL POLYPEPTIDE IN CORPUS CAVERNOSUM AND PERIPHERAL VENOUS-BLOOD DURING PROSTAGLANDIN E(1)-INDUCED ERECTION

Authors
KOEHN FM MISKA W SCHILL WB WEIDNER W WEISKE WH
Citation
Fm. Koehn et al., CONCENTRATIONS OF VASOACTIVE INTESTINAL POLYPEPTIDE IN CORPUS CAVERNOSUM AND PERIPHERAL VENOUS-BLOOD DURING PROSTAGLANDIN E(1)-INDUCED ERECTION, Archives of andrology, 31(3), 1993, pp. 217-222
Citations number
26
Categorie Soggetti
Andrology
Journal title
Archives of andrology → ACNP
ISSN journal
01485016
Volume
31
Issue
3
Year of publication
1993
Pages
217 - 222
Database
ISI
SICI code
0148-5016(1993)31:3<217:COVIPI>2.0.ZU;2-O
Abstract
Vasoactive intestinal polypeptide (VIP) hits been suggested to play a role as a nonadrenergic, noncholinergic neurotransmitter or neuromodul ator involved in the process of erection. Until now, data about fluctu ating concentrations of VIP in corpus cavernosum (CC) blood have been controversial. The present study describes a modified radioimmunoassay method that was developed in our laboratory for the determination of VIP in plasma. Examination of 12 patients suffering from impotentia co eundi (6 men with psychogenic impotence, 2 with induratio penis plasti ca, and 4 with impotence of vascular origin) showed that the concentra tions of VIP in corpus cavernosum blood during pharmacologically induc ed erection did not increase in organically healthy men or in men with impotentia coeundi of vascular origin. The VIP concentrations in peri pheral venous blood and those in CC blood were similar.