J. Kleisner et T. Imfeld, EVALUATION OF THE EFFICACY OF INTERDENTAL CLEANING DEVICES - HOW TO DESIGN A CLINICAL-STUDY, Journal of clinical periodontology, 20(10), 1993, pp. 707-713
A review of the literature was made, focusing on experimental designs
used in clinical studies for assessment of the efficacy of interdental
cleaning aids with regard to plaque removal and the prevention of car
ies and gingivitis. After careful consideration of the pros and cons o
f published procedures, an experimental design for such studies is pro
posed.