BLOOD-GLUCOSE AND INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE BY PATIENTSWITH CHRONIC CHAGAS-DISEASE AND ALCOHOLISM

Citation
Lcm. Oliveira et al., BLOOD-GLUCOSE AND INSULIN-RESPONSE TO INTRAVENOUS GLUCOSE BY PATIENTSWITH CHRONIC CHAGAS-DISEASE AND ALCOHOLISM, Brazilian journal of medical and biological research, 26(11), 1993, pp. 1187-1190
Citations number
13
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
0100879X
Volume
26
Issue
11
Year of publication
1993
Pages
1187 - 1190
Database
ISI
SICI code
0100-879X(1993)26:11<1187:BAITIG>2.0.ZU;2-U
Abstract
Blood glucose and insulin responses to intravenous glucose 500 mg/kg i n a group of alcoholic chagasic patients (Group I, N = 15) were assess ed and compared to those of a group of patients with Chagas' disease w ithout alcoholism (Group II, N = 16), a group of alcoholics without Ch agas' disease (Group III, N = 22), and a group of non-alcoholics witho ut Chagas' disease (Group IV, N = 15). Determinations of serum glucose and insulin were done under fasting conditions, 5 and 10 min after th e injection of 50% glucose. There was no difference in mean serum gluc ose levels between groups. Mean serum insulin levels at times 5 and 10 min and for the total integrated response were lower (P<0.05) in Grou ps I and II as compared to Group IV; at time 10 min the mean was lower (P<0.05) in Group III as compared to Group IV. There was a nonsignifi cant trend for a lower insulinemic response in Group I as compared to Group II. These data suggest denervation of or injury to pancreatic B cell by Chagas' disease.