NON-CALCIFYING PINDBORG TUMOR WITH LANGERHANS CELLS

A rare case of calcifying epithelial odontogenic tumor (CEOT) devoid o f calcification is reported with histochemical, immunohistochemical an d electron microscopic studies. The tumor occurred intraosseously in t he left maxillary canine and premolar region of a 58-year-old man. The tumor chiefly consisted of scattered small islands of epithelial cell s in an abundant fibro-myxoid connective tissue stroma. Among the nest s, there were many spherical bodies of eosinophilic substance for whic h non-AA amyloid and non-keratin or basal lamina-like natures were dem onstrated histochemically and immunohistochemically. In some nests, th ere were a few, occasionally several, cells positive for S-100 protein . Ultrastructurally, Langerhans cells with indented nuclei and Birbeck 's granules were seen among tumor cells. The prognostic significance o f the paucity of calcification and the presence of Langerhans cells in CEOT of which this is only the second description is discussed.