SILICONE-RUBBER - HYDROGEL COMPOSITES AS POLYMERIC BIOMATERIALS .5. TRANSDERMAL THERAPEUTIC SYSTEMS BASED ON HYDROGEL FILLED SILICONE-RUBBER

Authors
DUCKOVA K KUCERA J VONDRACEK P LOPOUR P
Citation
K. Duckova et al., SILICONE-RUBBER - HYDROGEL COMPOSITES AS POLYMERIC BIOMATERIALS .5. TRANSDERMAL THERAPEUTIC SYSTEMS BASED ON HYDROGEL FILLED SILICONE-RUBBER, European journal of pharmaceutics and biopharmaceutics, 39(5), 1993, pp. 208-211
Citations number
NO
Categorie Soggetti
Pharmacology & Pharmacy","Engineering, Chemical
Journal title
European journal of pharmaceutics and biopharmaceutics → ACNP
ISSN journal
09396411
Volume
39
Issue
5
Year of publication
1993
Pages
208 - 211
Database
ISI
SICI code
0939-6411(1993)39:5<208:S-HCAP>2.0.ZU;2-#
Abstract
The paper evaluates powder-like hydrogels based on polymers and copoly mers of 2-hydroxyethylmethacrylate (HEMA) and methacrylic acid (MAA) a s potential pharmaceutical adjuvants. The possibility of use of these substances in the form of composite materials with silicone rubber as matrices for transdermal therapeutic systems was studied. The rate of release of nitroglycerin from the matrices at discontinuous sink condi tions was measured and evaluated using a Tornquist hyperbolic function . The results show that the HEMA-MAA copolymers are prospective adjuva nts for use in transdermal therapeutic systems.