The cause of cardiac tamponade is only established in 50% of cases. Th
is problem is most commonly treated by pericardiocentesis alone, peric
ardiotomy being reserved for cases of recurrence and pericardiectomy f
or those patients presenting with constrictive pericarditis. A series
of 16 patients treated with pericardial fenestration via a thoracoscop
e is presented. Pericardial and pleural biopsies were performed, toget
her with cytological and biochemical analysis of the pericardial and p
leural fluid where present. This procedure established the aetiology o
f effusion in all cases. In malignant pericardial effusion bleomycin w
as used for pericardial sclerosis. This resulted in fewer recurrences
than in those patients where sclerosis was not attempted (12.5% v 60%)
.