RELEASE OF OFLOXACIN FROM SILICONE GEL SHEET

From a drug delivery system using silicone gel, the amount of Ofloxaci n (OFLX) released or transferred to a wound and blood was measured ove r 2 weeks. From three types of silicone gel containing 2, 0.2 and 0.02 % OFLX respectively, levels from that with 2% OFLX were highest, appro ximately two to five times higher than that with 0.02% OFLX. Statistic ally significant differences were found between the three types (P < 0 .01, Student's t-test). When used in partial thickness skin wounds on rats, only an extremely small amount of OFLX was detected in the serum , being higher under gel containing 2% OFLX. In a clinical study, howe ver, no drug was detected either in the blood or the wound after 1 wee k.