A COMPARATIVE BURN WOUND MODEL IN THE NEW YORKSHIRE PIG FOR THE HISTOPATHOLOGICAL EVALUATION OF LOCAL THERAPEUTIC REGIMENS - SILVER SULFADIAZINE CREAM AS A STANDARD

A standard burn wound model was developed in the pig to enable evaluat ion of histopathological parameters of wound healing under different c ircumstances. Wounds on one flank were treated with silver sulfadiazin e 1% cream (SSD, Flammazine-Duphar), which is a standard treatment. On identical places of the contralateral side different topical agents w ere applied. From the SSD treated burns a typical histopathologic pict ure of wound heating under SSD could be derived: SSD has the potential to preserve viable dermal tissue, epidermal regeneration is rather sl ow and irritated, while the formation of granulation tissue is pronoun ced, with an abundance of myofibroblasts.