The anatomy of the mesocolon can be seen on computed tomographic (CT)
scans, and its CT anatomy can be described by using the vessels in the
mesocolon as anatomic landmarks. Knowledge of this anatomy is the bas
is to understanding pathologic processes involving the mesocolon. Comm
on pathologic conditions usually occur due to spread of disease betwee
n organs to which the mesocolon is attached, primarily the colon and p
ancreas. The disease may be a malignant lesion, a benign inflammatory
process, or, rarely, a primary tumor of the mesocolon; the mode of spr
ead may be via the lymphatic vessels, direct extension, vascular invas
ion, or vascular involvement. The authors demonstrate various patholog
ic conditions and modes of spread, as seen on CT scans, with emphasis
on disease of the colon and pancreas. The pathway for the spread of di
sease and its progression in these organs can be predicted in patients
with a known disease. More important, identification of abnormalities
in the mesocolon leads to careful evaluation of the organs to which t
he mesocolon is attached.