IGG2 DEFICIENCY IN CHILDREN WITH FEBRILE CONVULSIONS - A FAMILIAL STUDY

The IgG subclasses were investigated in children with febrile convulsi ons (FC) and in their first degree relatives in the search for a selec tive immunological deficiency associated with FC and its occurrence in the relatives of affected subjects. The results of the study show low er IgG2 concentrations in FC patients than in controls. But it was not possible to demonstrate familial transmission of the IgG2 subclass de ficiency, since it was present only in children with FC and tended to normalize in adulthood. The immunoglobulin subclass deficiency might b e responsible for the recurrent infections connected with FC.