CAUDAL HINDBRAIN NEUROMEDIN B-PREFERRING RECEPTORS PARTICIPATE IN THECONTROL OF FOOD-INTAKE

Recent studies have identified two subtypes of bombesin (BN) receptors in the rat central nervous system: gastrin releasing-peptide (GRP) pr eferring and neuromedin B (NMB) preferring. To investigate a role for the NMB-preferring receptor subtype in feeding suppression elicited by fourth ventricular (4V) BN administration, we evaluated the ability o f a selective NMB-preferring receptor antagonist, BIM-23127, to block suppression of glucose intake produced by 4V BN (10 pmol). Our results showed that 4V administration of BIM-23127 dose dependently antagoniz ed the suppression of glucose intake produced by 4V BN. In addition, 4 V administration of BIM-23127 alone increased glucose intake above tha t observed in the baseline condition. These results support a role for the NMB-preferring BN receptor subtype in the suppression of intake p roduced by 4V BN administration and suggest that endogenously released NMB participates in ingestive control.