RADIATION-ASSOCIATED ANGIOSARCOMA OF THE SMALL-BOWEL - A CASE OF MULTIPLOIDY AND A FULMINANT CLINICAL COURSE - CASE-REPORT

Angiosarcoma developing in unusual sites such as the gastrointestinal tract is not uncommonly associated with a known eliciting factor. Thus , among hitherto reported cases of angiosarcoma of the small bowel, fi ve were radiation-associated. One additional example of ileal angiosar coma induced by therapeutic irradiation of endometrial carcinoma is he rein reported as a reminder of this causal association. DNA analyses o f the primary growth as well as the metastatic deposits showed at leas t four aneuploid cell clones indicating genetic instability. This obse rvation corresponds to the consistently poor prognosis of radiation-as sociated angiosarcoma of the small bowel.