Purpose: The purpose of this study was to compare the results of peron
eal bypass grafting for limb salvage with the results of other tibial
and pedal bypass grafts performed concurrently. Methods. Thirty-four p
eroneal bypass grafts with autologous vein were performed for limb sal
vage between September 1986 and June 1992. These constituted 18% of an
overall experience of 194 tibial or pedal bypasses performed during t
hat time. Preoperative and intraoperative arteriograms were reviewed t
o identify anatomic characteristics associated with successful limb sa
lvage. Results. Secondary patency rates for peroneal bypass grafts (70
%) compared with the other tibial and pedal bypass grafts (65%) did no
t differ significantly at 48 months by life-table analysis. Limb salva
ge achieved by peroneal artery bypass grafting was significantly worse
(55%) than that achieved by the remaining tibial and pedal bypasses (
67%) at 48 months. Limb salvage was 33% at 7 months for those undergoi
ng peroneal artery bypass grafting as opposed to 57% at 48 months for
patients undergoing other tibial or pedal revascularizations with tiss
ue necrosis. Four anatomic features were identified that were associat
ed with failure after peroneal artery bypass grafting. These were pero
neal length less than 10 cm (p = 0.012), peroneal artery diameter less
than 2 mm (p = 0.035), absence of arteriographically demonstrated col
laterals perfusing the foot (p = 0.0001), and little or no visualizati
on of the pedal arch (p = 0.008).Conclusions: Although successful graf
ts may avoid amputation in carefully selected cases, alternatives to p
eroneal artery bypass grafting should be considered when less than fav
orable anatomic conditions are encountered, particularly in the presen
ce of forefoot tissue necrosis.