We investigated the prevalence of stone disease and urinary stone risk
factors in machinists chronically exposed to a hot environment and ma
ssive sweating, without interference of nephrotoxic metals or other li
thogenic compounds. The study was performed at a glass plant and expos
ure to heat stress was estimated by the Wet Bulb Globe Temperature cli
matic index. The prevalence of nephrolithiasis on the entire populatio
n of the machinists was 8.5% (20 of 236), while the prevalence on the
controls working in normal temperature was 2.4% (4 of 165) (p = 0.03).
A high incidence (38.8%) of uric acid stones was present in the worke
rs exposed to heat stress. Among the urinary stone risk indexes determ
ined for 3 days during the 8-hour work shift on a randomly selected sa
mple of 21 workers exposed and 21 workers not exposed to heat stress w
ithout any evidence of stone disease significant differences were foun
d in uric acid concentration (722 +/- 195 versus 482 +/- 184 mg./l., p
<0.001), specific gravity (1,026 +/- 4 versus 1,021 +/- 6, p <0.005)
and pH (5.31 +/- 0.28 versus 5.64 +/- 0.54, p <0.02), respectively. Th
us, high uric acid relative supersaturation was present during occupat
ion in hot temperatures (8.67 +/- 3.49) compared to occupation in norm
al temperatures (4.15 +/- 2.7) (p <0.001). This study confirms that ch
ronic dehydration represents a real lithogenic risk factor, mainly for
uric acid stones, and adequate fluid intake is recommended during hot
occupations.