PROSTATE-SPECIFIC ANTIGEN LEVELS IN MEN OLDER THAN 50 YEARS WITHOUT CLINICAL-EVIDENCE OF PROSTATIC-CARCINOMA

In their derivation of normal prostate specific antigen (PSA) levels ( 0 to 4.0 ng./ml.) Hybritech used almost exclusively men less than 60 y ears old. The purpose of this study was to define PSA levels by age de cade in men older than 50 years without clinical evidence of prostatic carcinoma or so-called cancer-free. We define the cancer-free populat ion as men with a PSA less than or equal to 4.0 ng./ml. and nonsuspici ous digital rectal examination, and those with an abnormality in eithe r parameter with a nonmalignant prostate biopsy. A total of 755 men wa s recruited for a prostate cancer detection study using serum PSA and digital rectal examination, of whom 728 fulfilled our criteria of canc er-free. Newly derived mean and standard deviation were 1.32 +/- 1.10 ng./ml. in the 50 to 59-year group, 1.91 +/- 1.72 ng./ml. in the 60 to 69-year group and 2.36 +/- 1.98 ng./ml. in the 70 to 79-year group. T he upper limits for PSA (mean + 2 standard deviations) by age were 3.5 ng./ml. in the 50 to 59-year group, 5.4 ng./ml. in the 60 to 69-year group and 6.3 ng./ml. in the 70 to 79-year group. The apparent accurac y of these new limits is strong in the 60 to 69-year group but it decl ines in the next decade. The data support further attempts at using PS A, age and digital rectal examination to establish selection criteria for prostate biopsy with adequate sensitivity and specificity.