SEVERE CYCLOPHOSPHAMIDE-INDUCED HEMORRHAGIC CYSTITIS SUCCESSFULLY TREATED BY TOTAL CYSTECTOMY WITH ILEAL NEOBLADDER SUBSTITUTION - A CASE-REPORT

A 45-year-old woman with intractable cyclophosphamide-induced hemorrha gic cystitis was successfully treated with total cystectomy and ileal neobladder substitution. To our knowledge this is the first reported r econstruction of the lower urinary tract in a patient with acute hemor rhagic cystitis using a neobladder. Neobladder substitution is contrai ndicated if the urethra or bladder neck is involved in the disease, al though neither was involved in our patient. Whether these lesions are generally left intact has not been discussed previously. If a neobladd er can be used, life threatening hemorrhagic cystitis should be treate d with total cystectomy accompanied by immediate neobladder substituti on.