CINERADIOGRAPHIC ANALYSIS OF ANTROPYLOROB ULBAR CONTRACTILITY IN DIABETICS - EFFECT OF ERYTHROMYCIN

We studied antropyloroduodenal contractility in diabetics and the effe ct of erythromycin IV (100-500 mg) using the non invasive Boiron ciner adiographic method analysis. Fourteen diabetics and 22 controls were e xamined. Four hours after a standard liquid-solid meal, patients drank 250 mL baryum solution. Fluorographic plates (10 x 10 cm) were taken every 2 s during 30 s. Semi-automatic data processing analysis allowed to measure motility parameters including antral (CA) and bulbar (CB) contractility indexes; pyloric opening index (OP), gastric (FG) and bu lbar (FB) frequencies. Three types of pylorus behaviour patterns were define : A and B related to antropyloric and antropyloroduodenal coord ination respectively and N without coordination. In diabetics, CA, OP and FG were decreased vs controls (P < 0.01) (CA: 65.5 +/- 6.8 vs 83.1 +/- 2,4 %; OP. 60.9 +/- 8.7 vs 84.8 +/- 1.9 %; FG: 2.42 +/- 0.14 vs 3 .08 +/- 0.04 c/min) and antropylorobulbar coordination altered (N was predominant; no bulbar cycles at 3/min). Antral hypocontractility was correlated with autonomic neuropathy. After erythromycin, radiogical p arameters returned to normal values (CA = 83.0 +/- 2.4 %; OP = 86.0 +/ - 4.7 %; FG = 3.0 +/- 0.16 c/min) and coordination improved type N dis appeared and FB = 3 c/min (58 %). Cineradiographic analysis is simple, able to show antropylorobulbar contractile abnormalities, to study ph armacological effects, and in diabetics is capable of studying improve ment of motility parameters with erythromycin.