Fifty-eight patients, 31 women and 27 men, with a wide range of upper
arm circumferences (20-43 cm), ages (16-82 years) and body mass indice
s (16-55 kg m-2) were studied. The direct blood pressure was measured
in the brachial artery in one arm and simultaneously the indirect pres
sure was measured in the other arm using a large standard cuff (rubber
bag 12 x 35 cm). The mean intra-arterial blood pressure was (systolic
/diastolic) 137 +/- 25 mmHg (SD)/76 +/- 10 mmHg. With the cuff the mea
n blood pressure was 134+/- 23 mmHg/85 +/- 11 mmHg. The cuff significa
ntly underestimated the systolic blood pressure (3.2 +/- 11.4 mmHg, ra
nge -25-30 mmHg) while the diastolic pressure was overestimated signif
icantly (8.8 +/- 8.5 mmHg, range -32-14 mmHg). The direct/indirect blo
od pressure difference correlated significantly to the intraarterial s
ystolic and diastolic pressures (systolic/diastolic; r = 0.44, P = 0.0
006/r = 0.36, P = 0.0062), but only to the auscultatory diastolic pres
sure (r = -0.02, P = 0.9/r = -0.45, P = 0.0004). The direct/indirect d
ifference correlated significantly to the arm circumference (r= -0.33,
P = 0.01/r = -0.30, P = 0.02) as did the diastolic direct/indirect di
fference to pulse rate (r = 0.34, P = 0.009). Age did not correlate si
gnificantly to the direct/indirect blood pressure difference in this s
tudy (r = -0.02, P = 0.9/r = -0.10, P = 0.5). It can be concluded that
in addition to the ratio between the arm circumference and the width
of the cuff (rubber bag), there are other sources of systematic errors
of indirect blood pressure measurement, in particular pulse rate and
the level of indirect blood pressure. If corrections could be made wit
h regard to these variables, it is obvious that the reliability of the
indirect method, especially when used in epidemiological contexts, wo
uld increase.