Bone marrow transplant (BMT) recipients frequently develop rashes as a
consequence of their disease, its treatment or because of a complicat
ion such as infection. These rashes are often clinically atypical, yet
appropriate management is dependent upon correct diagnosis and theref
ore a skin biopsy is often performed. In a group of 101 consecutive BM
T recipients, 25 patients had a total of 34 skin biopsies. A specific
histopathological diagnosis was made in 65% (22/34), including graft v
s. host disease (GVHD) (1 5 cases), infection (4 cases), drug reaction
(i case) and recurrent lymphoma (1 case). Therapy was changed followi
ng the biopsy in 77% (17/22) of these cases. In 35% (12/34) the histol
ogical changes were non-specific, however, in 10 of these cases GVHD h
ad been suspected clinically and its exclusion was therefore useful. S
kin biopsy is of considerable value in the diagnosis and subsequent ma
nagement of BMT recipients who develop a rash.