ELECTROPHYSIOLOGICAL CHANGES ACCOMPANYING DSP-4 LESIONS OF RAT LOCUS-CERULEUS NEURONS

Authors
MAGNUSON DSK STAINES WA MARSHALL KC
Citation
Dsk. Magnuson et al., ELECTROPHYSIOLOGICAL CHANGES ACCOMPANYING DSP-4 LESIONS OF RAT LOCUS-CERULEUS NEURONS, Brain research, 628(1-2), 1993, pp. 317-320
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
628
Issue
1-2
Year of publication
1993
Pages
317 - 320
Database
ISI
SICI code
0006-8993(1993)628:1-2<317:ECADLO>2.0.ZU;2-0
Abstract
The electrophysiological characteristics of intracellularly recorded l ocus coeruleus (LC) neurons in brain stem slices from DSP-4 treated an imals have been compared to those from untreated controls. LC neurons from DSP-4 treated animals had action potentials and Ca2+ spikes (elic ited in the presence of TTX) of significantly reduced duration compare d to controls. These observations suggest that chemical axotomy with D SP-4 reduces Ca2+ conductance in neurons of the locus coeruleus.