ENHANCEMENT OF BONE-FORMATION IN RABBITS BY RECOMBINANT HUMAN GROWTH-HORMONE

Authors
EHRNBERG A BROSJO O LAFTMAN P NILSSON O STROMBERG L
Citation
A. Ehrnberg et al., ENHANCEMENT OF BONE-FORMATION IN RABBITS BY RECOMBINANT HUMAN GROWTH-HORMONE, Acta orthopaedica Scandinavica, 64(5), 1993, pp. 562-566
Citations number
33
Categorie Soggetti
Orthopedics
Journal title
Acta orthopaedica Scandinavica → ACNP
ISSN journal
00016470
Volume
64
Issue
5
Year of publication
1993
Pages
562 - 566
Database
ISI
SICI code
0001-6470(1993)64:5<562:EOBIRB>2.0.ZU;2-6
Abstract
We studied the effect of human recombinant growth hormone on diaphysea l bone in 40 adult rabbits. The diaphyseal periosteum of one femur in each animal was mechanically stimulated by a nylon cerclage band. The bands induced an increase in bone formation, bone mineral content, and maximum torque capacity of the diaphyseal bone at 1 and 2 months. Gro wth hormone enhanced the anabolic effect of the cerclage bands on- bon e metabolism, evidenced by a further increase in torsional strength of the femurs.