THE ANALYSIS OF IFOSFAMIDE AND ITS METABOLITIES - (REVIEW)

Ifosfamide is a member of the oxazaphosphorine class of cytostatic dru gs. Ifosfamide has to be metabolized prior to expressing its cytotoxic ity. This metabolism leads to a great variety of metabolites. An overv iew 'is given of the methods of analysis of ifosfamide and its metabol ites as well as the current knowledge about its metabolism, toxicity a nd clinical use in relation to the bio-analysis. For ifosfamide and so me of its metabolites reliable methods of analysis exist. However, for the most important metabolites, isofosforamide mustard and acrolein, progress has to be made in improving the simplicity and sensitivity of the existing methods.