HEMATOTOXICITY OF 5-FLUOROURACIL AND ALPHA-INTERFERON ON THE HUMAN NORMAL HEMATOPOIETIC PROGENITORS

Citation
G. Castello et al., HEMATOTOXICITY OF 5-FLUOROURACIL AND ALPHA-INTERFERON ON THE HUMAN NORMAL HEMATOPOIETIC PROGENITORS, Anticancer research, 13(5A), 1993, pp. 1477-1480
Citations number
16
Categorie Soggetti
Oncology
Journal title
ISSN journal
02507005
Volume
13
Issue
5A
Year of publication
1993
Pages
1477 - 1480
Database
ISI
SICI code
0250-7005(1993)13:5A<1477:HO5AAO>2.0.ZU;2-V
Abstract
The toxic effects of a combination of 5 fluorouracil (5-FU) and interf eron a on normal human hemopoietic progenitors were assessed in vitro. CFU-GM growth was evaluated following 1 h incubation of bone marrow c ell suspension with 5-FU 100 mug/ml or IFN-alpha2a 1000 U/ml, or with both drugs, either simultaneously or sequentially added. IFN-alpha did not show toxic effects on normal human hemopoietic progenitors and th e severe toxicity of 5-FU on the latter was not modified by IFN-alpha. These results suggest that the changes observed in vivo of 5-FU toxic ity induced by IFN-alpha should be attributed to indirect effects of t he latter.