G. Castello et al., HEMATOTOXICITY OF 5-FLUOROURACIL AND ALPHA-INTERFERON ON THE HUMAN NORMAL HEMATOPOIETIC PROGENITORS, Anticancer research, 13(5A), 1993, pp. 1477-1480
The toxic effects of a combination of 5 fluorouracil (5-FU) and interf
eron a on normal human hemopoietic progenitors were assessed in vitro.
CFU-GM growth was evaluated following 1 h incubation of bone marrow c
ell suspension with 5-FU 100 mug/ml or IFN-alpha2a 1000 U/ml, or with
both drugs, either simultaneously or sequentially added. IFN-alpha did
not show toxic effects on normal human hemopoietic progenitors and th
e severe toxicity of 5-FU on the latter was not modified by IFN-alpha.
These results suggest that the changes observed in vivo of 5-FU toxic
ity induced by IFN-alpha should be attributed to indirect effects of t
he latter.