RESULTS OF OFLOXACIN THERAPY IN ANDROLOGICAL PATIENTS SUFFERING FROM THERAPY-REQUIRING ASYMPTOMATIC INFECTIONS

In 1990, microbiological ejaculate analyses were carried out on a rout ine basis on 125 andrological patients, in addition to the determinati on of the concentration, motility and morphology of the spermatozoa. F ourteen patients (11.2%) with therapy-requiring asymptomatic infection s (TAI) > 10(4) CFU (colony-forming units) ml-1 were effectively treat ed with Ofloxacin (Tarivid(R)) at 2 x 200 mg d-1 for a period of 20 d. Concentration, motility and morphology of the spermatozoa were determ ined before the Ofloxacin treatment and controlled 1, 3, and 6 months later and correlated to the values obtained before the treatment. Over the entire period of observation, the morphology did not change signi ficantly, whilst initially 1 month after the treatment the concentrati on and the motility decreased significantly (P<0.05). Three months lat er they again reached the starting values. After 6 months, a significa nt improvement occurred with regard to the motility, as compared to th e starting values (P<0.01), whilst the concentration remained at the l evel of the starting values. By this, Ofloxacin has been proved to be an effective medication for the treatment of TAI. In the end, it still remains an open question whether the improvement in sperm motility is primarily related to the Ofloxacin therapy.