TOTAL SYNTHESIS OF THE SPIROKETAL MACROLIDE (+) MILBEMYCIN ALPHA(1)

Authors
LEY SV MADIN A MONCK NJT
Citation
Sv. Ley et al., TOTAL SYNTHESIS OF THE SPIROKETAL MACROLIDE (+) MILBEMYCIN ALPHA(1), Tetrahedron letters, 34(46), 1993, pp. 7479-7482
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
46
Year of publication
1993
Pages
7479 - 7482
Database
ISI
SICI code
0040-4039(1993)34:46<7479:TSOTSM>2.0.ZU;2-J
Abstract
The total synthesis of the antiparasitic spiroketal macrolide (+) milb emycin alpha1 is reported, following Julia sulfone anion coupling of t he sulfone 3 with a northern hemisphere aldehyde 2 and subsequent func tional group elaboration.