PROLINE 4-HYDROXYLASE - STEREOCHEMICAL COURSE OF THE REACTION

Authors
BALDWIN JE FIELD RA LAWRENCE CC MERRITT KD SCHOFIELD CJ
Citation
Je. Baldwin et al., PROLINE 4-HYDROXYLASE - STEREOCHEMICAL COURSE OF THE REACTION, Tetrahedron letters, 34(46), 1993, pp. 7489-7492
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
34
Issue
46
Year of publication
1993
Pages
7489 - 7492
Database
ISI
SICI code
0040-4039(1993)34:46<7489:P4-SCO>2.0.ZU;2-J
Abstract
The stereochemical course of the hydroxylation of (S)-proline by proli ne 4-hydroxylase from Streptomyces griseoviridus has been investigated using (2S, 4S)-[4-H-2(1)]-proline and (2S, 4R)-[4-H-2(1)]-proline and found to occur with retention of stereochemistry at C-4 of proline.