RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) DOES NOT STIMULATE IN-VIVO TUMOR-GROWTH OF THE HUMAN COLON-CANCER CELL-LINE HTB 38 WHICH IS RESPONSIVE IN-VITRO

Authors
KOENIGSMANN M TOPP MS THIEL E BERDEL WE
Citation
M. Koenigsmann et al., RECOMBINANT HUMAN GRANULOCYTE-COLONY-STIMULATING FACTOR (RHG-CSF) DOES NOT STIMULATE IN-VIVO TUMOR-GROWTH OF THE HUMAN COLON-CANCER CELL-LINE HTB 38 WHICH IS RESPONSIVE IN-VITRO, International journal of oncology, 3(6), 1993, pp. 1057-1059
Citations number
13
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
3
Issue
6
Year of publication
1993
Pages
1057 - 1059
Database
ISI
SICI code
1019-6439(1993)3:6<1057:RHGF(D>2.0.ZU;2-D
Abstract
Haematopoietic growth factors such as human granulocyte colony-stimula ting factor (G-CSF) have been shown to stimulate in vitro growth of so me human solid tumour cell lines. Among these is the human colorectal adenocarcinoma cell line HTB 38. The in vivo relevance of this finding was tested by xenografting HTB 38 cells intracutaneously into athymic nu/nu BALB/c mice. Recombinant human (rh) G-CSF was administered as a subcutaneous bolus twice daily from day 1 to 14 after tumour transpla ntation at a dose level of 312 mug/kg/day. Serum levels of rhG-CSF wer e within the range required for the in vitro effect. However, the cyto kine caused no significant growth modulation of the tumour in vivo.