ANTITUMOR EFFECT OF K+ H+-ANTIPORTER NIGERICIN ON HUMAN LUNG-CARCINOMA GROWN IN IN-VIVO-LIKE HISTOCULTURES/

Authors
BAIBAKOV BA FRANK GA MARGOLIS LB SKULACHEV VP
Citation
Ba. Baibakov et al., ANTITUMOR EFFECT OF K+ H+-ANTIPORTER NIGERICIN ON HUMAN LUNG-CARCINOMA GROWN IN IN-VIVO-LIKE HISTOCULTURES/, International journal of oncology, 3(6), 1993, pp. 1127-1129
Citations number
7
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
3
Issue
6
Year of publication
1993
Pages
1127 - 1129
Database
ISI
SICI code
1019-6439(1993)3:6<1127:AEOKHN>2.0.ZU;2-D
Abstract
Small shifts of intracellular pH (pH(i)) play a crucial role in many c ellular functions, in particular progression through the cell cycle. W e present results demonstrating that in the majority of cases, nigeric in shows cytostatic effect on tumor cells in the in vivo-like 3-dimens ional histocultures of human lung tissues while the normal tissue rema ins morphologically intact.