CYTOSTATIC EFFECT OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE (PMEA) .2. LYMPHOBLASTIC-LEUKEMIA IN SPRAGUE-DAWLEY RATS

Authors
OTOVA B SLADKA M BLAZEK K SCHRAMLOVA J VOTRUBA I HOLY A
Citation
B. Otova et al., CYTOSTATIC EFFECT OF 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE (PMEA) .2. LYMPHOBLASTIC-LEUKEMIA IN SPRAGUE-DAWLEY RATS, Folia biologica, 39(3), 1993, pp. 142
Citations number
17
Categorie Soggetti
Biology
Journal title
Folia biologica → ACNP
ISSN journal
00155500
Volume
39
Issue
3
Year of publication
1993
Database
ISI
SICI code
0015-5500(1993)39:3<142:CEO9(.>2.0.ZU;2-V
Abstract
Two cases of spontaneous acute lymphoblastic leukemia in the inbred st rain of Sprague-Dawley (Prague) rats have been observed. Since its rel iable transplantability in syngeneic recipients was established, leuke mic animals were used to test the cytostatic effect of PMEA. The treat ment resulted in a significant prolongation of survival time of the tr eated animals. At the same time histological examination of PMEA-treat ed and untreated animals indicated that the drug effectively slows dow n the growth of lymphoma at the site of inoculation and inhibits the s ubsequent progression of tumor cells in the lung, liver, spleen and ly mph nodes.