ANTIMITOTIC AND TERATOGENIC EFFECTS OF ACYCLIC NUCLEOTIDE ANALOGS 1-(S)-(3-HYDROXY-2-PHOSPHONOMETHOXYETHYL)CYTOSINE (HPMPC) AND 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE (PMEA)

Authors
BILA V OTOVA B JELINEK R SLADKA M MEJSNAROVA B HOLY A KREN V
Citation
V. Bila et al., ANTIMITOTIC AND TERATOGENIC EFFECTS OF ACYCLIC NUCLEOTIDE ANALOGS 1-(S)-(3-HYDROXY-2-PHOSPHONOMETHOXYETHYL)CYTOSINE (HPMPC) AND 9-(2-PHOSPHONOMETHOXYETHYL)ADENINE (PMEA), Folia biologica, 39(3), 1993, pp. 150-161
Citations number
24
Categorie Soggetti
Biology
Journal title
Folia biologica → ACNP
ISSN journal
00155500
Volume
39
Issue
3
Year of publication
1993
Pages
150 - 161
Database
ISI
SICI code
0015-5500(1993)39:3<150:AATEOA>2.0.ZU;2-3
Abstract
The acyclic nucleotide analogues, HPMPC and PMEA, differ in their in v itro effect on the genetic material of eukaryotic cells. While HPMPC e xerts a cytostatic effect on eukaryotic cells in vitro, PMEA has a gen otoxic activity. These results correspond with the mode of embryotoxic action of these compounds : HPMPC exhibits a general embryolethal eff ect, whereas PMEA is apparently teratogenic and interacts with the mut ant allele producing preaxial polydactyly of the hind limbs.