A FORMAL SYNTHESIS OF APLYSIATOXIN - ENANTIOSELECTIVE SYNTHESIS OF KISHI ALDEHYDE
Citation
H. Okamura et al., A FORMAL SYNTHESIS OF APLYSIATOXIN - ENANTIOSELECTIVE SYNTHESIS OF KISHI ALDEHYDE, Tetrahedron, 49(46), 1993, pp. 10531-10554
Categorie Soggetti
Chemistry Inorganic & Nuclear
SICI code
0040-4020(1993)49:46<10531:AFSOA->2.0.ZU;2-0
Abstract
This paper describes the enantioselective synthesis of key fragments (
12, 18, 24, and 35) for the synthesis of aplysiatoxin (1a), a potent c
ancer promoter, and their convergent assembly to Kishi's aldehyde (2).
Since 2 has already been transformed into 1a in a short step, its syn
thesis constitutes a formal total synthesis of 1a.
