THE BIOSYNTHESIS OF THE MOLD METABOLITES ROQUEFORTINE AND ASZONALENINFROM L-[2,4,5,6,7-H-5(2)] TRYPTOPHAN

Authors
BHAT B HARRISON DM LAMONT HM
Citation
B. Bhat et al., THE BIOSYNTHESIS OF THE MOLD METABOLITES ROQUEFORTINE AND ASZONALENINFROM L-[2,4,5,6,7-H-5(2)] TRYPTOPHAN, Tetrahedron, 49(46), 1993, pp. 10663-10668
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
49
Issue
46
Year of publication
1993
Pages
10663 - 10668
Database
ISI
SICI code
0040-4020(1993)49:46<10663:TBOTMM>2.0.ZU;2-0
Abstract
L-[2,4,5,6,7-H-2(5)]Tryptophan was incorporated into roquefortine 2 by Penicillium roqueforti and aszonalenin 3 by Aspergillus zonatus with retention in each case of five deuterium atoms; the 5a-hydrogen of bot h metabolites is derived from the 2-hydrogen of tryptophan.