IMMUNE RECONSTITUTION FOLLOWING PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION, AUTOLOGOUS BONE-MARROW TRANSPLANTATION AND ALLOGENEIC BONE-MARROW TRANSPLANTATION

The rate and pattern of recovery of total lymphocytes, T cell subsets, B cells and NK cells were compared for 12 months following recovery p hase peripheral blood stem cell (PBSC) autotransplantation (n = 49), a utologous (n = 7) and allogeneic BMT (n = 11). The PBSC group had a si gnificantly faster recovery of total lymphocyte count, total T cells ( CD3+ cells), CD8 cells and CD4 cells than the allogeneic BMT group. Th e pattern of earlier recovery of CD8 cells than CD4 cells was the same for each type of transplant. Reconstitution following autologous BMT was intermediate between PBSC and allogeneic BMT. Multivariate analysi s identified type of transplant, number of mononuclear cells transplan ted and conditioning regimen as significantly influencing immune recov ery.