AN IMMUNODOMINANT SEQUENTIAL EPITOPE RECOGNIZED BY MOUSE ANTI-RECOMBINANT BOVINE GROWTH-HORMONE ANTISERA

Authors
BEATTIE J BORROMEO V FAWCETT HAC SECCHI C
Citation
J. Beattie et al., AN IMMUNODOMINANT SEQUENTIAL EPITOPE RECOGNIZED BY MOUSE ANTI-RECOMBINANT BOVINE GROWTH-HORMONE ANTISERA, Immunology letters, 38(1), 1993, pp. 41-45
Citations number
19
Categorie Soggetti
Immunology
Journal title
Immunology letters → ACNP
ISSN journal
01652478
Volume
38
Issue
1
Year of publication
1993
Pages
41 - 45
Database
ISI
SICI code
0165-2478(1993)38:1<41:AISERB>2.0.ZU;2-B
Abstract
The sequential epitopes on bovine growth hormone (bGH) recognised by f ive polyclonal mouse antisera have been identified by scanning with mu ltiple pin-bound peptides. Four main epitopes were identified at resid ues 29-40, 101-110, 139-152 and 181-191. Of these, only epitope 139-15 2 is recognised by all five mouse antisera, indicating that, for the m ouse, this may represent an immuno-dominant region of the bGH molecule .