DOSE-RESPONSE RELATIONSHIP OF ATRACURIUM BESYLATE IN THE HALOTHANE-ANESTHETIZED PIG

Authors
SHORTEN GD GIBBS NM
Citation
Gd. Shorten et Nm. Gibbs, DOSE-RESPONSE RELATIONSHIP OF ATRACURIUM BESYLATE IN THE HALOTHANE-ANESTHETIZED PIG, Research in Veterinary Science, 55(3), 1993, pp. 392-393
Citations number
5
Categorie Soggetti
Veterinary Sciences
Journal title
Research in Veterinary Science → ACNP
ISSN journal
00345288
Volume
55
Issue
3
Year of publication
1993
Pages
392 - 393
Database
ISI
SICI code
0034-5288(1993)55:3<392:DROABI>2.0.ZU;2-K
Abstract
The dose response relationship for the intermediate-acting non-depolar ising muscle relaxant, atracurium besylate in the pig was determined u sing evoked electromyography. An incremental dose technique was used i n seven Large White/Landrace crossbred pigs anaesthetised with nitrous oxide and halothane. ED50 and ED95 were 510 +/- 87 mug kg-1 and 1150 +/- 270 mug kg-1, respectively. Although these values may represent an overestimate, they provide a reasonable guideline for the use of atra curium by veterinary anaesthetists.