NA(-ATPASE OF GASTRIC CELLS - A TARGET OF HELICOBACTER-PYLORI CYTOTOXIC ACTIVITY(),K(+))

Authors
RICCI V SOMMI P COVA E FIOCCA R ROMANO M IVEY KJ SOLCIA E VENTURA U
Citation
V. Ricci et al., NA(-ATPASE OF GASTRIC CELLS - A TARGET OF HELICOBACTER-PYLORI CYTOTOXIC ACTIVITY(),K(+)), FEBS letters, 334(2), 1993, pp. 158-160
Citations number
21
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
334
Issue
2
Year of publication
1993
Pages
158 - 160
Database
ISI
SICI code
0014-5793(1993)334:2<158:NOGC-A>2.0.ZU;2-F
Abstract
The present study shows a direct impairing action of a cytotoxin-produ cing Helicobacter pylori strain on the Na+,K+-ATPase (evaluated as K+- dependent phosphatase activity) of human gastric epithelial cells in c ulture. The toxin itself is likely involved in this action which may a lso account for the cell edema found in vivo in Helicobacter pylori-co lonized stomach.