Two new collagen-like loci have been identified in the human genome wh
ich have sequence similarity to the triple-helical coding region of th
e pro-alpha2(I) gene. Both loci exhibit length polymorphism due to all
eles that contain deletions. The deletion at one locus is 400 bp while
the deletion at the second locus is 200 bp. The second locus is on ch
romosome 17 and its two alleles are not in Hardy-Weinberg equilibrium.
These loci are candidates for involvement in connective tissue disord
ers.