Hm. Hoyeraal et al., CHARACTERIZATION OF RESPONDERS AND NONRESPONDERS TO TIAPROFENIC ACID AND NAPROXEN IN THE TREATMENT OF PATIENTS WITH OSTEOARTHRITIS, Journal of rheumatology, 20(10), 1993, pp. 1747-1752
Objective. To characterize responders/nonresponders to 2 nonsteroidal
antiinflammatory drugs by a combination of start variables in the trea
tment of patients with osteoarthritis (OA) of the hip(s)/knee(s). Meth
ods. Two hundred eight patients participated in a 3-week randomized do
uble blind parallel group trial. Results. The responder rate to tiapro
fenic acid and naproxen was 52 and 59%, respectively. Correctly charac
terized by use of a combination of 6 baseline variables were 79% of th
e patients treated with tiaprofenic acid and 81% treated with naproxen
. Conclusion. Both active drugs were found effective compared with pla
cebo in patients with OA, but with different characteristics.